Methyl 1-hydroxycyclopropanecarboxylate

Name	Methyl 1-hydroxycyclopropanecarboxylate
Synonyms	1-hydroxycyclopropyl acetate Methyl 1-hydroxycyclopropanecarboxylate Methyl 1-Hydroxycyclopropanecarboxylate Methyl 1-Hydroxycyclopropane-1-carboxylate Methyl 1-hydroxy-1-cyclopropane carboxylate METHYL 1-HYDROXY-1-CYCLOPROPANE CARBOXYLATE, 90 1-Hydroxycyclopropanecarboxylic Acid Methyl Ester Cyclopropanecarboxylic acid, 1-hydroxy-, methyl ester cyclopropanecarboxylic acid, 1-hydroxy-, methyl ester
CAS	33689-29-1
InChI	InChI=1/C5H8O3/c1-8-4(6)5(7)2-3-5/h7H,2-3H2,1H3

Risk Codes	11 - Highly Flammable
Safety Description	16 - Keep away from sources of ignition.
UN IDs	3277
HS Code	29162090

Introduction	Methyl 1-hydroxy-1-cycloprocarboxylate is an organic intermediate. Because many compounds containing cyclopropane substructural units have good biological activity, cyclopropane has a very wide range of applications in drug design.
Uses	Methyl 1-hydroxy-1-cycloprocarboxylate is a carboxylate organic substance and can be used as an intermediate in organic synthesis.
preparation	1-aminocyclopropyl methyl ester (3.41g,29.6mmol,1.0eq) is dissolved in 40ml of sulfuric acid aqueous solution a (1.62mL of 98% concentrated sulfuric acid is added to water to prepare, the molar equivalent of sulfuric acid is 1.0eq), the ice bath is cooled to 0-5 ℃, and 10ml of sodium nitrite (2.25g,32.6mmol,1.1eq) aqueous solution, stirring at room temperature for 1 hour. Then the above reaction droplets are added to the refluxed 100ml sulfuric acid aqueous solution B (obtained by adding 1.62mL 98% concentrated sulfuric acid into water, and the molar equivalent of sulfuric acid is 1.0eq). After dropping, stop heating and cool to room temperature. After TLC detection reaction is completed, ethyl acetate (3*100mL) is extracted three times, the organic phase is combined, dried with anhydrous magnesium sulfate, filtered and concentrated the organic phase to obtain methyl 1-hydroxy -1-cycloprocarboxylate (2.57g,22.1mmol), colorless oily liquid, and the yield is 74.8%.

Last Update：2024-04-09 21:01:54